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They may also apply a topical anesthetic cream or spray to numb the skin surface

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Lam CS, Ramasundarahettige C, Branch KR, Sattar N, Rosenstock J, Pratley R, et al

Contraindications may be associated with specific health conditions

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SCFAs activate receptors (FFAR2, FFAR3 / GPR41, GPR43) on L-cells GLP-1 release