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Nat Rev Neurosci 12(11):638651 Ramey T, Regier PS (2019) Cognitive impairment in substance use disorders

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The amino terminus of chemokines interacts with the extracellular portion of chemokine receptors that are members of the G protein-coupled receptor (GPCR) family

For someone already close to frailty thresholds, a 1 to 2 kg hit to lean mass can dramatically reduce chair-stand time and raise the fall risk, which is why the quality of weight loss becomes extremely important in these patients