semaglutide hold before surgery New Study Recommends Stopping GLP-1 Agonists 14 Days Total Joint Arthroplasty to Reduce Anesthesia Risks Should I Take Ozempic® Before

Grimm M, Han J, Weaver C, Griffin P, Schulteis CT, Dong H, Malloy J (2013) Efficacy, safety, and tolerability of exenatide once weekly in patients with type 2 diabetes mellitus: an integrated analysis of the DURATION trials

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Combination Approaches Future treatments might combine incretin agonists with other weight loss mechanisms like metabolism boosters, appetite suppressants working through non-incretin pathways, or fat absorption inhibitors

doi: 10.1016/j.cmet.2019.07.013 16 MeierJJGoetzeOAnstippJHagemannDHolstJJSchmidtWEet al

The key regulatory milestones: FDA Breakthrough Therapy designation for MASH (September 2024) EMA PRIME designation for MASH (November 2023) China NMPA Breakthrough designation (June 2024) Phase 3 trials (SYNCHRONIZE-1 and SYNCHRONIZE-2) fully enrolled, results expected H1 of this year Estimated FDA filing: Late this year at the earliest Estimated FDA approval: Possibly next year, depending on Phase 3 results If Phase 3 results confirm Phase 2 findings, survodutide could reach the market within the next 12-24 months

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