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While MERS-CoV has been found to productively infect macrophages 45 , SARS-CoV infection of macrophages is abortive and does not alter the pro-inflammatory cytokine gene expression profile after antibody-dependent uptake 41,42
With millions of users worldwide, the pharmacovigilance signal is clear: reporting odds ratio of 2.46 for alopecia compared to other medications
Research results from this therapy are mixed
The intranasal formulations are not approved to treat acute B12 deficiency
The most useful nuance for readers comparing headlines: REDEFINE 1's 20.4% number is the treatment-policy estimand (closer to intention-to-treat what happens regardless of whether participants stayed on treatment)
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