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The compounds quinolinium scaffold mimics nicotinamides structure, allowing it to compete for the NNMT active site while avoiding interactions with other enzymes

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Pickart, L., Margolina, A

Inflammopharmacology (Springer) 2026

this was due to a blunted inflammatory response to the DSS insult 68,69

The peptides anxiolytic mechanism appears to involve favoring natural homeostasis of the GABA receptor complex and enhancing GABAergic transmission through distinct, non-benzodiazepine pathways