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They generally improve cardiovascular outcomes and have a low risk of causing hypoglycemia compared to other diabetes medications

As a result, targeting a single metabolic pathway may not lead to sustained therapeutic responses, as compensatory mechanisms can activate other pathways, undermining the treatments efficacy

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The SELECT cardiovascular outcomes trial further demonstrated a 20% reduction in major adverse cardiovascular events in overweight and obese adults (Lincoff et al., 2023)

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