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The GSH- and cysteine-conjugates produced are susceptible to thiol exchange reactions and may act as carbamoylating agents towards biomacromolecules (Guan et al., 2002)

Eryptosis evaluations may play a role in the toxicological characterization of new substitutes for existing compounds

Vitamins E, A and B2 as possible risk factors for preeclampsia under consideration of the PROPER study (prevention of preeclampsia by high-dose riboflavin supplementation)

More explanatory evidence in the future will require the simultaneous reporting of metabolites/metabolic ratios and cellular phenotypic outputs within a unified network framework, together with the integration of multi-model data stratified by tissue and disease stage, so as to move from pathway-level associations toward definable metabolic nodes and translatable therapeutic windows

Epub 2013 Apr 6

The UK regulator recommends that in adults weighing less than 50 kg, clinical judgement should be employed when prescribing oral paracetamol as these patients may be at increased risk of hepatotoxicity but does not specify a dose reduction