Mechanism descriptions reflect findings reported in the preclinical and basic-research literature
Zhong L, Huang X, Karperien M, Post JN (2015) The regulatory role of signaling crosstalk in hypertrophy of MSCs and human articular chondrocytes
Caspase-1, an inflammatory mediator, can activate pro-inflammatory cytokines (IL-1 and IL-18) and participate in the initiation of inflammation [83]
CYP51A1-mediated cholesterol metabolism affects the synthesis of sex hormones and glucocorticoids, which can lead to heart defects and skeletal abnormalities [83, 84]
Step 3: Glutathione assembly Finally, the building blocks come together: Cysteine + glycine + glutamate = glutathione
1B) while no expression was shown for those genes in the primary cells