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The initial trial that used empagliflozin published in 2015, through to the most recent trial that used efpeglenatide published in 2021 were evaluated in detail in the accompanying systematic review and meta-analysis

While TRP itself did not show a notable change, its indole-containing metabolite I3AA was significantly elevated, as was the ratio of I3AA/TRP, possibly indicating a shift away from the serotonergic pathway of TRP metabolism

Vilsboll T, Agerso H, Krarup T, and Holst JJ