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NICE guidelines (NG28) recommend GLP-1 receptor agonists for type 2 diabetes based on individual patient factors, including cardiovascular risk, and not strictly as second- or third-line therapy after metformin failure

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Dietary structure High-fat diets alter normal metabolic circadian rhythms in mice ( in vitro culture of the NCI-H716 human intestinal cell line revealed that nutrients such as palmitic acid, oleic acid and meat hydrolysates can stimulate GLP-1 secretion in a dose-dependent manner ( in vitro cultures of mouse mGLUTag L cells ( Figure 1 )