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Early work, including in the Journal of Medicinal Chemistry, has mapped these relationships to guide the design of next-generation NNMT inhibitors

For example, its involved in the synthesis of the inflammatory mediators leukotrienes and prostaglandins

NNMT inhibition follows dose-dependent curves: 50mg produces 4050% enzyme inhibition, 100mg achieves 6075%, with diminishing returns beyond 150mg

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You can have the perfect storage conditions, but if you're introducing contaminants with every use, it won't matter