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A decade ago, if someone told me we'd be discussing 30% weight loss from a subcutaneous injection, I would have called it fantasy

Zhao, J., Wu, Y., Liang, S

GLP-1

43% of people on a GLP-1 reach the 1.2 g/kg protein target 4665% stop within 12 months cost and side effects lead ~ of lost weight tends to return within a year without a plan On muscle loss the honest version: About 40% of the weight lost in the STEP-1 trial was lean mass (Neeland 2024)

But Engel said that had he or his physicians been aware of the possible link to the eye condition that could cause permanent blindness, something that seemed far from a simple side effect, he would have reconsidered taking it and certainly would have stopped taking it after his first eye stroke

Healthcare providers may also recommend starting with a lower dosage and titrating to minimize side effects