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As for the use of COMT-I, has been linked to a reduced incidence of LDopa-associated PN regardless of disease duration and severity, likely due to the positive impact on Hcy production (Phokaewvarangkul et al

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It is generally recommended to avoid alcohol while using this medication as it can interfere with the absorption of vitamin B12

possible transient effects may include flushing, headache, or injection-site reactions

1 mM EDTA

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