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Two randomized double-blind placebo-controlled trials using 50200 mg/day of riboflavin had failed to produce any significant benefit in migraine prophylaxis involving 5- to 15-year-old patients (100)

This discouragement often leads to premature discontinuation, as evidenced by real-world data showing that 75% of patients without meaningful early weight loss will not achieve clinically significant results after six months of behavioral therapy alone

Usually mild and diminishing with continued use