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QZ: Investigation, Writing review & editing

Thebault, J

It is used mainly as add-on to metformin when metformin alone is insufficient for glycemic control, particularly when there is a desire to minimize the risk for hypoglycemia

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Emerging opportunities for the treatment of metabolic diseases: Glucagon-like peptide-1 based multi-agonists

In order to lower glucose, GIP travels to beta cells in the pancreas and activates GIP receptors (GIPr) via class-II G-protein coupled receptors causing an increase in intracellular cAMP and calcium leading to a release of insulin [3]