Bottom Line on Effectiveness: Tirzepatide Alternatives: Mounjaro, Zepbound, and properly compounded tirzepatide all produce 15-22% average weight loss Choose based on cost, availability, and conveniencenot effectiveness concerns Semaglutide Alternatives: Wegovy, Ozempic, and properly compounded semaglutide all produce 10-15% average weight loss Slightly less potent than tirzepatide but still highly effective Best value for weight loss medication The active ingredient determines effectiveness, not the brand name on the label
it cannot establish superiority, because differences in population, comparator, endpoint, dose, and trial length confound any direct read
Participants starting above 300 pounds lost more total pounds than those starting at lower weights, though percentage losses were similar
Petraeus and Maj
Avoid repeated freezing and thawing, which may accelerate degradation
GLP-1 medications are powerful tools for weight management