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Figure 4 5 Research progress on amino acid metabolism in autoimmune-related diseases The studies described above indicate that different amino acid metabolic pathways can influence macrophage polarization through mechanisms such as substrate competition, signal transduction, TCA cycle anaplerosis, and epigenetic regulation

2.1.3.8 Patient factors (age, comorbidity) matter An older patient or one with diabetes may already have baseline mitochondrial dysfunction and altered immunometabolism ( e.g

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TDO is abundantly present in melanomas, bladder carcinomas, and hepatocarcinomas

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