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Park D, Spencer JA, Koh BI, Kobayashi T, Fujisaki J, Clemens TL, Lin CP, Kronenberg HM, Scadden DT

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This model synthesizes currently available correlative and mechanistic evidence to systematically examine interactions between mitochondria and other pivotal organelles, integrating their functional coordination, dynamic alterations, and potential pathological implications during ovarian aging (Fig

Oral Protocol Essentials Standard dose: 5001,000 mcg, 12 daily Empty stomach for systemic effects: 3060 minutes before meals or 2 hours after With food for gut-coating effects: take alongside meals Storage: capsules should be refrigerated

Gclc f/f mice (hereafter described as Gclc WT) were also treated with tamoxifen to control for potential confounding effects associated with tamoxifen treatment