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As oxidative stress increases, further stimulation of pro-inflammatory cytokines such as TNF- and IL-1 increases and contributes to synaptic dysfunction and neuronal degeneration ( These studies suggest that the loss of antioxidant defense is an early biochemical event rather than a late-stage consequence of neuronal death

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10.1186/s12974-019-1434-3 67 MaY.ZhangY.JiangH.XiangS.ZhaoY.XiaoM.et al (2021)

MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease

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Intermediate papers connect ideas to structured endpoints