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One such option is GLP-1 therapy, which includes medications such as semaglutide ( Ozempic , Wegovy) and liraglutide (Saxenda, Victoza)
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Given that the glucose-lowering effect of metformin is so strong and is independent of incretin signalling, it might be difficult to detect the beneficial effect of metformin on the incretin axis in human studies
Alleva R., Nasole E., Di Donato F., Borghi B., Neuzil J., Tomasetti M
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