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Notably, by using a Met antagonist (ethionine) and a product of Met metabolism (SAM) in vitro , Ikeda et al

Second, regarding the monitoring, be aware that future monitoring may involve cardiovascular biomarkers like NT-proBNP, hs-CRP, and potentially novel fibrosis markers like endotrophin, rather than just monitoring A1C and body mass index

VK0214 is currently being evaluated in a Phase 1b clinical trial in patients with the adrenomyeloneuropathy (AMN) form of X-ALD