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The small study didnt have wildly convincing statistical significance when comparing treatment to sham (p=0.07, one-sided)
doi: 10.3389/fendo.2025.1570603 Received 03 February 2025 Accepted 29 April 2025 Published 21 May 2025 Volume 16 - 2025 Edited by Jared Rutter, The University of Utah, United States Reviewed by Steven Patterson, Glasgow Caledonian University, United Kingdom Elena Jimenez Marti, University of Valencia, Spain Nigel Irwin, Ulster University, United Kingdom Updates Copyright 2025 Koefoed-Hansen, Helsted, Kizilkaya, Lund, Rosenkilde and Gasbjerg
However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]
When not to use Before using this supplement, inform your doctor about your complete medical history
protocols are individualized
They also cause your stomach to process food more slowly, leaving you feeling fuller, longer
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