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Its concentration increased significantly under the influence of 8 days of water-only fasting, but the exercise test did not modify these changes

75 Their effect on adipogenesis in vitro goes through down-regulation of C/EBP, PPAR, SREBP1, leptin, FABP4, and adiponectin

Accessed May 12, 2025

The peptide has been the subject of multiple in vitro and animal studies (and a smaller number of human observational studies) published in Bulletin of Experimental Biology and Medicine , Biogerontology , and other journals

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