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Among this group, beneficiaries who were flagged as having diabetes (not including Type 1 Diabetes Mellitus) based on ICD-10 codes and using the same requirements as the CCW DIABETES flag, were identified as being eligible for GLP-1s approved for use as diabetes treatments

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Weight loss reduces mechanical stress on weight-bearing joints, with each pound lost decreasing knee loading by approximately 3-4 pounds during walking

This observation is consistent with the relatively minimal effect of BETP on signaling of the potent GLP-1R endogenous agonist GLP-1, compared to the weaker agonist GLP-1(9-36)amide, whose effects are potentiated by BETP ( 21 )

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Bravenboer B, Kappelle AC, Hamers FP, van Buren T, Erkelens DW, Gispen WH