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i , Doseresponse curves for control (shCtrl) and Smurf1 knockdown (shSmurf1-1/shSmurf1-2) HCT116 cells treated with SMART1 or SMART1Et for 72 h (4 independent experiments)

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The threshold concentration for tubular reabsorption (above which the fractional reabsorption begins to decline) is about 40-60 umol/L, which is similar to the endogenous plasma L-carnitine level

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