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Some people find that appetite suppression decreases somewhat over time

Endocrinologist (2009) 19(3):11921

This class of drugs have been around for 20+ years so we do know the most common side effects are GI in nature (nausea, vomiting, constipation and diarrhea), Kaplan said

People with mild B12 deficiencies experience changes in B12 effectiveness yet severe deficiencies need extended treatment time or stronger doses to produce noticeable results

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