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Patients above age 18 years, who were diagnosed with Type 2 diabetes with no record of smell or taste disturbances, were split into two groups: patients prescribed Type 2 diabetes medications that were not GLP-1s (control) and patients who received GLP-1 prescriptions after their first recorded diagnosis of Type 2 diabetes

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What makes this combination particularly intriguing is that these compounds work through entirely different biological pathways

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Under oxidative stress, CSF-cNs upregulated the activity of ATG4 by combining H 2 O 2 with the cysteine 81 sites of ATG4 and activated ATG4-promoted LC3 lipidation, which is essential for autophagy initiation, and promoted the formation of autophagosomes (Scherz-Shouval et al., 2007

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However, long-term risks such as rare adverse effects, metabolic effects over years, effects on bone, gallbladder, and pancreas need phase-3 trials and post-marketing surveillance to ensure the medication is safe for long-term use

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We provide realistic expectations based on current understanding of peptide therapy

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