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However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]
10.1007/s00299-017-2139-7 Plant Cell Rep
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In the mitochondria, more precisely in the ETC, some electrons escape at the level of complex I and III, and may interact with molecular oxygen to give rise to superoxide anions (O 2 ) (Turrens, 2003)
In addition, he explained the varied skin manifestations of syphilis presenting in three stages and internal organ involvement and called it a great imitator and treated the disease with mercury pills and iodides
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