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These perturbations lead to the release of mtDAMPs, rewire immune cell metabolism toward pro-inflammatory or immunosuppressive phenotypes, and impair the bioenergetic capacity needed for effective host defense and tissue repair ( Figure 2 )
Yunnan Provincial Major Science and Technology Special Plan, Biomedicine Special (202502AA310006)
Researchers continue to study how disturbances in the glutathione system may relate to atherosclerosis, vascular dysfunction, heart failure, and other cardiovascular conditions
These can include gastrointestinal issues, skin rashes, or allergic reactions in rare cases
Factors like stress, diet, and medications can disrupt the gut microbiome, weakening the immune system
