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(2015) Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility, Bioorg

These data imply that the absence of Gclc prevents B cells from establishing GC reactions, and therefore, hinders antibody production

In neurons, Grx has a protective effect on redox-sensitive enzymes and ion channels, meaning that its dysfunction is implicated in several neurodegenerative disorders involving protein misfolding and redox signaling dysregulation (Ogata et al., 2021)