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Front Neuroendocrinol 73: Rissman RA, Lee KF, Vale W, Sawchenko PE (2007) Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation

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Simultaneously, catalytically produced hydrogen peroxide (H 2 O 2 ) activates the protein transient receptor potential melastatin 2 (TRPM2) ion channel, promotes calcium influx, activates macrophages, and induces systemic immune response (Fig