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Effects of sodium-glucose cotransporter-2 inhibitor on atrial high-rate episodes in patients with cardiovascular implantable electronic device: a randomized controlled trial

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White WB, Cannon CP, Heller SR, Nissen SE, Bergenstal RM, Bakris GL, et al

Clinical guidelines generally support longer-term use for sustained outcomes, but the appropriate duration for how long to take GLP-1 medication should be guided by a prescriber based on individual goals, response to treatment, and overall health

While SURPASS-4 was not powered to evaluate differences in MACE-4 incidence between tirzepatide treatment groups and glargine, it was designed to fulfill the MACE-4 non-inferiority analysis requested by regulatory authorities to evaluate the cardiovascular safety of new glucose lowering medications