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To view digital features for this article go to Introduction Obesity (defined as a body mass index [BMI] 30 kg/m 2 in adults [1]) is a major health concern in the USA [2] and is associated with multiple complications, including cardiovascular disease, type 2 diabetes, and osteoarthritis [3,4,5,6,7,8]

In 1931 he recorded similar results in dogs (Creutzfeldt

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Lancet 365 , 13331346 (2005)

Marina Englesakis developed and performed the systematic literature search

Regulation of insulin secretion in human pancreatic islets