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A 2025 study in JAMA Network Open found that people with type 2 diabetes who took semaglutide (Ozempic) or tirzepatide (Mounjaro) had a 76% higher risk of developing a rare condition called nonarteritic anterior ischemic optic neuropathy (NAION)
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Review of Prostate Cancer Prevention Study Shows No Benefit for Use of Selenium and Vitamin E Supplements
This is not a concern for most patients who will need the medications, but it is a concern in an older population, since loss of muscle and bone accelerates and progresses past age 60
For a broader look at the SURMOUNT trial data and what it means clinically, the article on the SURMOUNT trials covers the key findings in detail
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