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Discontinuation rates due to adverse events in TRIUMPH-3 were 9.8% (9 mg) and 13.5% (12 mg) with retatrutide, compared with 4.8% for placebo
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In the SURPASS-2 trial, which compared tirzepatide to semaglutide 1 mg (a GLP-1 receptor agonist) over 40 weeks, participants receiving tirzepatide achieved A1C reductions of 2.01%, 2.24%, and 2.30% from baseline with the 5 mg, 10 mg, and 15 mg weekly doses, respectively
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[28] Other side effects reported were dyspepsia, constipation, abdominal pain, dizziness, and hypoglycemia
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