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Here is a proof-of-concept

The new results come on the heels of two other recent breakthroughs on antibiotic treatment from Collins group a report in Nature showing that viruses in the gut that infect bacteria harbor genes that confer antibiotic resistance, and another report in Science Translational Medicine showing that silver can boost the effectiveness of many widely used antibiotics

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In other words, without Parkin, PINK1 can induce lower mitophagy due to low basal mitochondrial ubiquitin levels, whereas Parkin can produce more ubiquitin substrates and induce robust and rapid mitophagy [48]