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By contrast, linagliptin and alogliptin bind within the enzyme's catalytically active pocket through interactions with both the S 1 /S 2 and S 1 '/S 2 ' binding sites, which are formed by a combination of aromatic amino acids, including Phe357, Tyr547, Tyr631, Tyr666, Trp629, and His740
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70 In addition, a clinical DDI study was conducted to investigate the inhibitory effect of the absorption enhancer for oral semaglutide (SNAC) on BCRP, OAT1/3, and OATP1B1 based on in vitro data
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The challenge is matching doses across formulations because oral semaglutide 14 mg daily roughly approximates injectable semaglutide 0.5-1.0 mg weekly in systemic exposure
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