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Take todays leading weight-loss drugs, for example

mass spectrometry-based methods have since confirmed circulating irisin in humans but at lower concentrations than initially reported (Jedrychowski et al., 2015)

This helps improve blood sugar in people with type 2 diabetes, but it also reduces appetite, leading to weight loss. Are Oral GLP-1s as Effective as Injectables

Research suggests that gastroparesis may be more common in patients who take GLP-1 drugs like Ozempic than in people who take other weight loss drugs

As you said, with GLP-1s, okay, they've been around for 20 years for folks with diabetes, but diabetes is kind of a unique context