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Additionally, improved glycemic control with GLP-1 RAs in T2DM patients may reduce glycosuria, a process known as glycemic buffering, which reduces caloric loss through urine and offsets part of the energy deficit induced by treatment [43,44,45]
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The dose starts low and increases over 16 weeks to reach the maximum dose for weight loss
Studies used a weekly schedule (SC) with gradual titration: in Phase 2, 1, 4, 8 and 12 mg once weekly
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