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Nitric Oxide (NO) pathway: It upregulates nitric oxide synthase, leading to vasodilation, improved blood flow, and reduced inflammation at injury sites
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Despite the huge difference in their numbers, with only a few thousand lymphocytes invading the brain and more than 50 times higher numbers of resident microglia, microglia could amplify the impact of T cells on the cerebral immune environment, making T cells the largest subtype of white blood cells contributing to secondary inflammatory damage after ischemia (70)
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