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One ligand interacts with the protein of interest (POI) while the other one recruits an E3 ubiquitin ligase, mostly CRBN (Cereblon) or VHL (Von Hippel-Lindau) 31,32

These megadoses often arent necessary, and in some cases could even be dangerous if they exceed the tolerable upper intake level

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Associate Professor, Human Nutrition Canada Research Chair Tier 2 in Micronutrients and Human Health The University of British Columbia The 2025 update was underwritten, in part, by a grant from Balchem Corporation

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Forty patients completed the study