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We discovered SnCE1 having an autoacetyltransferase (AcT) activity and confirmed earlier reports stating its weak DUB activity, cleaving Lys11-, Lys48- and Lys63-linked Ub chains but acting as an efficient deSUMOylase 26

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This calcium overload activates Tau kinases, such as GSK-3 and CDK5, thereby promoting Tau phosphorylation and exacerbating the pathological process of Alzheimers disease [117]

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Cardoso L, Rodrigues D, Gomes L, Carrilho F