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Pretreatment with AC significantly abated pre-hepatocarcinogenic indices proven by diminished HCC nodules, inflammatory interleukin-6, interferon-gamma, and tumor necrosis factor-alpha, as well as apoptotic caspase 3

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The rat studies producing the cardiovascular effects described above used 2 to 10 mcg/kg/day, which in a 70 kg adult would correspond to roughly 140 to 700 mcg/day, providing some rough allometric alignment with compounded doses but not a validated human dose