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Research published in JCI Insight describes tirzepatide as an "imbalanced and biased" dual agonist, meaning it shows equal affinity for the GIP receptor compared to native GIP but approximately 5-fold weaker affinity for the GLP-1 receptor compared to native GLP-1

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Same patient, same heart disease, same drug covered with a diabetes code, not covered without one. The MTA described Healeys reversal on copays and deductibles as a huge victory for workers, retirees and their families

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The highest dose outperformed liraglutide, which was notable because liraglutide was, at the time, a leading GLP-1 obesity treatment

Side effects were mostly mild #GI symptoms that improved over time