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Those who are allergic to Zepbound or Tirzepatide Those with type 1 diabetes Those with a family/personal history of thyroid cancer or thyroid problems People with a history of severe gastrointestinal disease Those with multiple endocrine neoplasia syndrome type 2 (MEN 2) People with disease of the pancreas (pancreatitis) Those with kidney disease Those who are pregnant or planning to become pregnant Those who are breastfeeding Speak with your medical provider before starting Zepbound if you have any of the above conditions or potential concerns

Clinical trials used doses as high as 1 mg per day without safety concerns, but 300 mcg is the most commonly referenced dose in peptide medicine literature and in the investigational protocols that have been published since the formal trials concluded

Yes, most people can take it daily

But if you tolerate it well, this is a clean starting point with 20-plus years of strain research behind it

SDH mutations in tumorigenesis and inherited endocrine tumours: lesson from the phaeochromocytoma-paraganglioma syndromes

Eur J Pediatr 2022;181:183557