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The activity of CAT in group 6 was recorded as 4.520.58, 4.960.22, and 5.260.37 on day 7, day 15, and day 30, respectively

By 104 weeks, approximately 77% of SELECT patients on dose were receiving the target semaglutide 2.4 mg weekly dose, which is lower than the corresponding proportion of patients in STEP 1 (89.6% were receiving the target dose at week 68) 14,21

For chronic weight management, the FDA-approved indications generally include adults with a BMI of 30 or greater, or BMI 27 or greater with at least one weight-related condition (type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease)

This stability makes it the preferred form for injectable formulations that users store in home refrigerators for weeks

Individuals with severe kidney disease should seek medical advice before starting this medication, as dehydration from side effects like vomiting may worsen kidney function

Chronic dehydration slows fat oxidation, reduces thermogenesis, and impairs cellular energy production