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Similar to the Trx system, using BSA-SSH, we found that, in the presence of NADPH, GR together with GSH has the potential to catalytically reduce protein persulfide species, with substantially increased reduction rates in the coupled assay with Grx (Fig
10.1038/cddis.2013.139 17 BrasierA
This corresponds to the observation that besides the downregulation of several CYPs, other CYP isoforms and further phase I metabolites were upregulated (Figure 2)
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