The FDA cited three concerns: potential immunogenicity (the peptide could trigger immune reactions), manufacturing impurity risks (synthetic peptides can contain truncated sequences and other contaminants), and a lack of human safety data sufficient to evaluate risk
Serious adverse events requiring immediate medical attention include: Pancreatitis: Severe abdominal pain, sometimes radiating to the back, with or without vomiting Gallbladder disease: Right upper quadrant pain, nausea, vomiting Acute kidney injury: Decreased urine output, swelling, fatigue Thyroid C-cell tumors (boxed warning for tirzepatide): Neck mass, difficulty swallowing, persistent hoarseness Metabolic considerations include the risk of hypoglycemia, particularly in patients with type 2 diabetes taking other glucose-lowering medications
Martnez-Cabanas, M., Lpez-Garca, M., Rodrguez-Barro, P., Vilario, T., Lodeiro, P., Herrero, R., Barriada, J
Doctors use blood tests to figure out whats going on
2019;179(7):1483-1498.e1422
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