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Here, we used the US Department of Veterans Affairs databases to build a cohort of people with diabetes who initiated GLP-1RA ( n = 215,970) and compared them to those who initiated sulfonylureas ( n = 159,465), dipeptidyl peptidase 4 (DPP4) inhibitors ( n = 117,989) or sodiumglucose cotransporter-2 (SGLT2) inhibitors ( n = 258,614), a control group composed of an equal proportion of individuals initiating sulfonylureas, DPP4 inhibitors and SGLT2 inhibitors ( n = 536,068), and a control group of 1,203,097 individuals who continued use of non-GLP-1RA antihyperglycemics (usual care)
Speller is required to determine candidacy
NAC supplements are the most well-studied source of cysteine, the linchpin of the glutathione chain
and limiting alcohol intake can reduce nausea and discomfort
Prioritising protein and fibre helps preserve muscle mass and manage side effects, while minimising ultra-processed foods supports the medications effectiveness
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