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Megaloblastic anemia Diminished activity of methionine synthase in vitamin B 12 deficiency inhibits the regeneration of tetrahydrofolate (THF) and traps folate in a form that is not usable by the body ( Figure 3 ), resulting in symptoms of folate deficiency even in the presence of adequate folate

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There was a one-week interval between each testing condition (drug or control treatment)

f We use topical anaesthetics to minimise pain

However, in the other 12 CVOTs of SGLT2is, allocation to a SGLT2i was not significantly associated with lower limb amputations (RR, 1.06

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